Fig. 3: Characterization of the structure and the catalase-like activity of Pt-HFn. | Nature Communications

Fig. 3: Characterization of the structure and the catalase-like activity of Pt-HFn.

From: Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization

Fig. 3

a Left: TEM image of Pt-HFn under negative staining conditions showing the morphology of the HFn shell. Right: Size distribution of HFn based on TEM analysis. Scale bar, 10 nm. b Left: TEM image of Pt-HFn under non-negative staining conditions showing the morphology of the Pt-core. Right: Size distribution of the Pt-core based on TEM analysis. Scale bar, 10 nm. c High-resolution TEM image of the Pt-core in Pt-HFn, with insets displaying atomic-level resolution images of selected areas and their corresponding fast Fourier transform (FFT) patterns. Scale bar, 2 nm. d TEM-EDS pattern of Pt-HFn, inset displaying the mass and atomic percentages of various elements present in the sample. e Upper: Schematic illustration of Pt-HFn catalyzing the decomposition of H2O2 to produce O2, mimicking catalase activity. Lower: Photographs of O2 bubble generation in H2O2 solutions for each group. f Changes in absorbance at 240 nm indicate the reduction of H2O2 content in H2O2 solutions for each group (n = 4 independent experiments). g Changes in dissolved oxygen content show the increase in O2 levels in H2O2 solutions for each group (n = 3 independent experiments). Data are shown as mean ± SEM. Source data are provided as a Source Data file.

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