Fig. 1: Structure of brachyury in complex with DNA. | Nature Communications

Fig. 1: Structure of brachyury in complex with DNA.

From: Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

Fig. 1

a Overall structure of human brachyury DNA binding ___domain with secondary structure elements labeled in accordance with the immunoglobulin fold nomenclature. b Structure of human brachyury bound to a palindromic DNA containing an inverted repeat of the T-box recognition element. Two brachyury protomers bind to each DNA half site with an unusual insertion of a helix into the minor groove and form a small interface between the two chains which is shown in the inset. c Details of the recognition of specific DNA base pairs by brachyury. For each nucleotide position in the T-box recognition element, the mode of recognition is indicated in the inset box with key residues and nucleotides labeled.

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