Table 1 Characteristics of the study cohorts

From: Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts

Cohort

Covid-19

Acute heart failure

Myocardial infarction

Stroke

Cohort size

 Pre exclusion

3948

3355

5560

3324

 Post exclusion

3650

2897

4524

2877

Demographics

 Age - yrs

61.8 (47.4–75.9)

74.2 (63.7–83.1)

68.9 (59.1–78.6)

70.7 (57.8–82.0)

 Gender - % male

56.00%

58.60%

64.20%

55.70%

 Self-reported Race -% white

58.90%

78.60%

76.70%

78.50%

 Self-reported Ethnicity - % hispanic

18.00%

8.00%

8.40%

7.30%

Biomarkers

 White blood cells (WBC) - ×103/µL

6.96 (5.19–9.49)

8.57 (6.66–11.11)

9.33 (7.19–12.25)

9.19 (7.02–12.42)

 Platelets (PLT) - ×103/µL

212 (164–274)

214 (165–273)

225 (181–276)

212 (168–266)

 Red cell distribution width (RDW) - %

13.5 (12.7–14.8)

15.1 (13.9–16.8)

13.6 (12.9–14.8)

13.5 (12.8–14.6)

 Abs lymphocytes (ALYMPH) - ×103/µL

1.05 (0.69–1.56)

1.20 (0.82–1.75)

1.60 (1.05–2.32)

1.38 (0.94–2.05)

 Abs monocytes (AMONO) - ×103/µL

0.55 (0.37–0.78)

0.69 (0.53–0.91)

0.70 (0.52–0.93)

0.66 (0.5–0.89)

 Abs neutrophils (ANEUT) - ×103/µL

4.94 (3.41–7.09)

6.18 (4.50–8.47)

6.34 (4.52–9.09)

6.50 (4.56–9.66)

Ratios

 Platelet-white cell (PWR)

30.8 (22.5–40.4)

25.1 (18.7–32.8)

24.1 (18.2–31.5)

22.5 (16.4–30.2)

 Monocyte-to-lymphocyte (MLR)

0.50 (0.31–0.81)

0.57 (0.38–0.86)

0.42 (0.28–0.68)

0.47 (0.3–0.74)

 Neutrophil-to-lymphocyte (NLR)

4.71 (2.68–8.17)

5.00 (3.12–8.41)

3.87 (2.26–7.41)

4.61 (2.53–8.65)

 Platelet-to-lymphocyte (PLR)

196.4 (131.9–304.7)

174.3 (115.3–264.2)

138.1 (95.7–211.8)

149.6 (99.5–224.1)

 RDW-to-platelet (RPR)

0.06 (0.05–0.08)

0.07 (0.05–0.09)

0.06 (0.05–0.08)

0.06 (0.05–0.08)

Outcomes

 30-day post-discharge, all-cause mortality

8.80%

8.70%

7.40%

14.00%

  1. Unless otherwise noted, data are presented as median (25th–75th percentiles). Pre and post exclusion refer to the requirement of blood count and differential availability. The overwhelming majority of exclusions occured due to lack of a white cell differential, while a standard blood count was available.
  2. PWR platelet-white ratio, MLR monotocyte-lymphocyte ratio, NLR neutrophil-lymphocyte rate, RPR red cell distribution width-platelet count ratio.