Fig. 6: A limited nucleotide exchange model for intermediate GPCR-Gαsβγ complex.
From: Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex

In the S5-mediated Gα the interaction between Cα5 and H1 helices was interrupted while this interaction is partially maintained through a weakened H-bond between Cα5 and H1 helices in Ras-like ___domain.