Fig. 5: Manhattan plots visualising overlap between various Genome-Wide Association Studies (GWASs) of smoking. | Nature Communications

Fig. 5: Manhattan plots visualising overlap between various Genome-Wide Association Studies (GWASs) of smoking.

From: A blood- and brain-based EWAS of smoking

Fig. 5

Studied phenotypes included: pack years (Generation Scotland, n = 17,105), pack years (largest meta-analysis to date21, n = 131,892), GrimAge-based DNAm estimator of smoking pack years (n = 17,105). The X-axis represents genomic positions, while the Y-axis shows −log10(P-values). The top horizontal line marks genome-wide significant associations (P < 5×10⁻⁸, red dots), based on the Bonferroni threshold for multiple testing. The bottom horizontal line denotes the suggestive significance threshold (P < 1x10⁻⁵, yellow dots). Dotted vertical lines mark genomic positions of significant associations at P < 5×10−8. All tests were two sided.

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