Fig. 4: Proteomic Clustering and molecular characteristics in ATC/PDTC tumors. | Nature Communications

Fig. 4: Proteomic Clustering and molecular characteristics in ATC/PDTC tumors.

From: Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers

Fig. 4

A Three subtypes (Pro-I, Pro-II, and Pro-II) of ATC and PDTC patients were divided based on protein expression profiles. The bottom heatmap shows the abundance of featured proteins in each subtype. The top heatmap shows the pathological characteristics of patients in three subtypes. B Kaplan–Meier curves (Log-rank test) showing significant differences in patient overall survival among different protein subtypes (Pro-I: 38 samples; Pro-II: 18 samples; Pro-III: 45 samples). C Bubble plot by Hypergeometric test showing pathways significantly enriched with differentially expressed proteins of three subtypes. D Heatmap showed the abundance of characteristic proteins under key regulatory pathways in three protein subtypes. E Radar plot showed differences in kinase family activity among three protein subtypes of patients. F Bar plot showed the activity of key regulatory kinases in three protein subtypes. G In the three protein subtypes, downstream regulatory substrates of significantly activated kinases involved in different signaling pathways. Source data are provided as a Source Data file.

Back to article page