Fig. 4: Determination of the contacts of Fab2-1 to the AAV9 capsid. | Nature Communications

Fig. 4: Determination of the contacts of Fab2-1 to the AAV9 capsid.

From: Structural characterization of antibody-responses following Zolgensma treatment for AAV capsid engineering to expand patient cohorts

Fig. 4

a The fit of the AAV9 capsid (yellow) and Fab2-1 (purple) models inside the cryo-EM map is shown. For further detail, the modeled CDR1-3 of the b heavy chain and c light chain inside the cryo-EM map are displayed. d Exemplary interactions of the Fab to the AAV9 capsid are shown.

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