Fig. 5: Network analyses and enrichment across CNS cell types, genetic risk, and differentially expressed genes. | Nature Communications

Fig. 5: Network analyses and enrichment across CNS cell types, genetic risk, and differentially expressed genes.

From: Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons

Fig. 5

Weighted Gene Co-expression Network Analyses (WGCNA) in (a) the subgenual Anterior Cingulate Cortex and (b) the Amygdala. Modules are labeled alphabetically, with association t-statistics on the Y-axis representing the strength of each module eigengene’s association with case-control status. The dotted line represents the FDR < 5% threshold. The heatmaps (lower panels) show specific enrichment for cell-type-specific expression profiles, MDD, PTSD, Alcohol Use Disorder (AUD), and Bipolar Disorder (BD) GWAS-based gene (MAGMA) analyses, along with differentially expressed genes from the current study. Enrichment p values (two-sided) that meet FDR < 5% are marked with stars in the relevant heatmaps.

Back to article page