Fig. 6: Role of JNK in cell competition.
From: Epithelial cell competition is promoted by signaling from immune cells
Hemocyte recruitment (A, C) and cell competition (B, D) in wing discs in which JNK signaling was manipulated. A, B Control and Myc clones were generated and hemocytes visualized as in Fig. 3, 72 h ACI; clones in Myc,bsk[1]/+ and Myc,bsk[1]/bsk[1] were created in wing discs carrying a heterozygous or homozygous bsk loss-of-function mutation (bsk1); In Myc,hml>bskRNAi and Myc,hml>bskDN discs bsk was specifically knocked down in hemocytes using bskRNAi or bskDN. n = 21, 15, 17, 7, 27, and 11 for the genotypes in (A), respectively. C, D clones were created as in A, B, but hemocytes were visualized by srpHemo-H2A-3xmCherry; clones denoted as “Control uniform Myc” were generated as in Fig. 1A; In clones marked Myc,arm>bskDN, bsk was knocked down everywhere using arm-Gal4 to drive UAS-bskDN. n = 10, 10, 10, and 8 discs for the genotypes in (C), respectively. *P < 0.05; ***P < 0.001; ****P < 0.0001 by two-sided Mann-Whitney U test. P value = 1.01 × 10−2, 1.00 × 100, 3.01 × 10-5, 2.15 × 10−4, 1.57 × 10−4, 1.36 × 10−4, 5.83 × 10−4, 1.13 × 10−2, 5.83 × 10−4, 3.30 × 10−2, 1.00 × 10-1, 1.57 × 10−4, 1.57 × 10−4, and 5.30 × 10−4, respectively. In each box and whisker plot, the box represents the interquartile, spanning from the first quartile to the third quartile, with a white line inside marking the median, and the whiskers show the range of the data, reaching the minimum and maximum values. Source data are provided as a Source Data file.
