Fig. 7: Lymphocytes from Infants express a broader ISG signature than those from adults. | Nature Communications

Fig. 7: Lymphocytes from Infants express a broader ISG signature than those from adults.

From: SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses

Fig. 7

a Pediatric and adult cohorts’ information. b UMAP plot representing clusters (n = 28) from 408,281 PBMCs and 79 samples (40 infants and 39 adults) c Cluster annotation. Dot plot represents expression values of selected genes (x-axis) across each cluster (y-axis). Dot size represents the percentage of cells expressing the marker of interest. Color intensity indicates the mean expression within expressing cells. d UMAP plots representing CD14+ monocyte subclusters (SCs; n = 4) and their respective annotations. e Bar plot showing the cell frequency of each CD14+ monocyte SC across the 79 individuals, as categorized by patient groups: pG1, pG2 and pG3; in purple, pHC in dark green, aG1, aG2 and aG3; in blue and aHC in light green. f As in (d) in CD4+ T cell SCs (n = 6). g As in (e) in CD4+ T cell SCs. h As in (d) in B cell SCs (n = 7). i As in (e) in B cell SCs. j Boxplot comparing the proportion of ISGhi CD14+ monocyte (SC1), CD4+ T cell (SC1) and B cell (SC3) subclusters across the individual (n = 79) in both pediatric (n = 40) and adult (n = 39) cohorts. P values were calculated using a two-sided t-test comparing the mean (G1, G2 or G3) with mean (pHC). ns: non-significant. The upper and lower bounds represent the 75% and 25% percentiles, respectively.

Back to article page