Fig. 3: Substrate scope for radical precursors and alkyne nucleophiles. | Nature Communications

Fig. 3: Substrate scope for radical precursors and alkyne nucleophiles.

From: Cu(I)-catalysed chemo-, regio-, and stereoselective radical 1,2-carboalkynylation with two different terminal alkynes

Fig. 3

a Scope of radical precursors and alkyl alkyne nucleophiles. Standard reaction conditions: S1 (2.0 equiv.), S16‒22 (0.20 mmol, 1.0 equiv.), radical precursor C1‒8 (2.0 equiv.), CuTc (10 mol%), L*8 (12 mol%), and Cs2CO3 (5.0 equiv.) in Et2O (4.0 mL) at 10 °C for 5 d under argon. b Scope of aryl alkyne nucleophiles. Standard reaction conditions: S1 (2.0 equiv.), S23‒27 (0.20 mmol, 1.0 equiv.), C1 (2.0 equiv.), CuTc (10 mol%), L*8 (12 mol%), and Cs2CO3 (5.0 equiv.) in Et2O (4.0 mL) at 10 °C for 5 d under argon. Isolated yield was shown; E.e. values were based on chiral HPLC analysis. Et ethyl, PMB 4-methoxybenzyl, Ac acetyl, Bn benzyl, Ts p-toluenesulfonyl, Ph phenyl, Boc t-butoxycarbonyl.

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