Fig. 6: Overview of the main conclusions of this study.
From: Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications
This figure summarizes the key findings of our study. We obtained a modular transcriptomic signature for the TB lesion that follows a gradual increase of differential expression relative to non-lesional tissue towards the center of the lesion, including the enrichment of gene modules associated with the immune response and inflammation within the lesion. The association of a worsened local status of the lesion with clinical and microbiological surrogates contributes to the immunopathological understanding of the disease and may aid in the clinical management of the disease by opening a window of opportunity for the adjustment of treatment. This figure was created in BioRender. Vilaplana, C. (2025) https://BioRender.com/f17r368.
