Fig. 8: Graphical abstract of the current study. | Nature Communications

Fig. 8: Graphical abstract of the current study.

From: Endolysosomal processing of neuron-derived signaling lipids regulates autophagy and lipid droplet degradation in astrocytes

Fig. 8

Inflammatory cytokine stimulates C1P biosynthesis in neurons. C1P and other lipid metabolites secreted by neurons are taken up by the astrocyte endolysosomes, where they are processed by resident enzymes. TTYH1 facilitates the extraction of C1P from endolysosomal membrane, which is necessary for maintaining autophagic flux and lipid droplet degradation. Excessive C1P internalized by astrocytes slows down autophagic flux and reduces lipid droplet degradation. These catabolic activities are further impaired upon TTYH1 deficiency, resulting in autophagic flux blockage and lipid droplet accumulation.

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