Fig. 3: Cell-type-specific genomic imprinting landscape.
From: Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals
a The number of the maternally and paternally expressed candidate imprinted genes in each cell type. b The imprinting status of candidate imprinted genes in Chromosome 1 and 2 of pigs across cell types. The average parental allele-specific expression ratio is shown for each candidate imprinted gene (0 means 100% biased paternal expression and 1 means 100% biased maternal expression). The stringent criteria were defined as average p1 > 0.70, p2 < 0.30 for maternal expression (MAT) and average p1 < 0.30, p2 > 0.70 for paternal expression (PAT), and each F1 replicate meeting cutoff of p1 > 0.70, p2 < 0.30 or p1 < 0.30, p2 > 0.70. The standard criteria were defined as the average allelic ratio > 0.70 for MAT or <0.30 for PAT. c Correlation between the detectable candidate imprinted genes and cell number of cell types. Pearson’s r and corresponding P values (two-sided t-test) are indicated. Source data are provided as Source Data file. d Bar plot showing the number of the candidate imprinted genes grouped by their imprinting status across different cell types and development stages. MAT maternal expression, PAT paternal expression, BAE biallelic expression, BVECs blood vascular endothelial cells, Fib fibroblast, HBCs Hofbauer cells, VSMCs vascular smooth muscle cells, AEC areolar epithelial cell, TPC trophoblast precursor cell, TC trophoblast cell, E40 embryonic day 40, E70 embryonic day 70.
