Fig. 6: Mechanism analysis of the wound healed through iSAFE treatment.
From: A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage
Representative immunostaining images for (a) cluster of differentiation 68 (CD68), interleukin 6 (IL-6), alpha smooth muscle actin (α-SMA) and Ki-67 (red) (Cell nuclei were stained with 4′, 6-diamidino-2-phenylindole (DAPI, blue)) from wound tissues after different treatments. Quantity analysis of the IHC staining (b) CD 68 positive rate, (c) average optical density (AOD) of IL-6, (d) α-SMA+ cells density, and (e) Ki-67 positive density of wounds with three different wound dressings after 6 days treatment (n = 3 independent replicates, one-way two-sided analysis of variance test, *P  <  0.05, **P  <  0.01, ***P  <  0.001 and ****P  <  0.0001, mean value ± SD). f Heatmap showing the comparison of differentially expressed genes (DEGs) in the wound tissues between the control group and the iSAFE treatment group (P < 0.05).
