Extended Data Fig. 7: Comparison of the selectivity filter of CNGC5, CNGC1 and the selected CNBD channels.

a, Sequence alignment of ion selectivity filter motifs in CNGC5, CNGC1 and other CNBD channels. b, Structure comparison of the selectivity filter of CNGC5Ca, CNGC1Ca and the selected CNBD channels. For clarity, only two diagonally opposed subunits are shown. The PDB accession numbers of the comparison channels are KAT1, 6V1X; HCN1, 5U6P; TAX-4, 6WEK.