Fig. 8: saeRS mutation or inhibition promotes in vivo clearance of implant-associated infections. | npj Biofilms and Microbiomes

Fig. 8: saeRS mutation or inhibition promotes in vivo clearance of implant-associated infections.

From: Staphylococcus aureus SaeRS impairs macrophage immune functions through bacterial clumps formation in the early stage of infection

Fig. 8

A Schematic illustration of implant-associated infection model and experimental procedures. B Representative images of the infection site on days 0, 4, 7, 10, and 14 after surgery in each treatment group. C, D Bacterial load of the implants and surrounding soft tissues in various groups on days 4, 7, and 14 after surgery (n = 6 per group). E Representative H & E images for each group on days 4, 7, and 14 after surgery (Scale bar, 100 μm, and 40 μm). F Representative Giemsa staining images for each group on days 4, 7, and 14 after surgery. Bacterial residue within the soft tissues is marked with red arrows (Scale bar, 20 μm, and 10 μm). ns: no significant, ** p ≤ 0.01, *** p ≤ 0.001. Data are presented as means ± SD. H & E, Hematoxylin and Eosin.

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