Fig. 5: Diagnostic power comparison of methylation markers and mammography.
From: Circulating cell-free DNA-based methylation patterns for breast cancer diagnosis
a, b The methylation panel has better diagnostic power [AUROC = 0.9815 (95% CI: 96.75–99.55%), and AUPRC = 0.9800 (95% CI: 96.6–99.4%)] than mammography [AUROC = 0.9315 (95% CI: 89.95–96.34%), and AUPRC = 0.9490 (95% CI: 91.7–98.1%)]. c, d The methylation markers and mammography combined model has obvious advantages in specificity of 98.67% and sensitivity for different stage with AUROC of 0.9951 (95% CI: 98.99–100%) and AUPRC of 0.955 (95% CI: 95.0–96.0%).
