Fig. 2: RPPA analysis of frozen core biopsies from tumors at baseline and following enzalutamide plus fulvestrant.

a Volcano plot of differences in baseline detection across the Long and Short PFS groups. b Differentially expressed phospho-proteins in the mTOR signaling pathway in Long PFS versus Short PFS at baseline. The lower and upper bounds of the boxes represent the first (Q1) and third (Q3) quartiles, respectively, which cover the interquartile range (IQR). The horizontal line within each box represents the median. The whiskers extending vertically out from the boxes are computed as Q1 − 1.5*IQR and Q3 + 1.5*IQR. Outliers are data points outside of this range and are indicated with dots. c Volcano plot of differences in fold change detection across Long and Short PFS groups. All statistical analyses were performed with the Bayes log2 two-sided moderated t-test.