Fig. 2: Overall agreement in the therapeutic indication given pre- and post-RS.

a Cohen’s kappa coefficients for pairwise inter-observer agreement on therapeutic recommendation pre- and post-RS result. b Change in Cohen’s kappa pre- and post-RS results for each pairwise comparison. c, d Cohen’s kappa coefficients for pairwise inter-observer agreement pre- and post-RS result by oncologist country (c) and experience (d). In (a, c and d), each dot represents the result of a pairwise comparison between two oncologists for every patient. The p values (Wilcoxon test) refer to the comparison between the overall agreement pre-RS and post-RS. The horizontal lines in the boxes denote the first quartile, median, and third quartile. The boundaries of the whiskers are based on the 1.5 × interquartile values.