Table 2 Genome-wide significant SNPs among Africans and replication among ARIC African Americans

From: Genome-wide association study for proliferative diabetic retinopathy in Africans

 

AADM

ARIC-AA

Meta-analysis

SNPs

Genes

Chr:Pos (bp)

Effect/Ref. Alleles

EAF/N

OR

95% CI

Genotype Counts

P-values

Info score

EAF/N

OR

95% CI

p-values

Info score

OR

95% CI

P-values

rs12906891

WDR72

15:53864144

T/C

0.07/291

1.46

1.30,1.64

Ca: 38/24/2

Co: 214/13/0

9.7E−10

0.94

0.14/79

1.10

1.41,1.93

0.41

0.96

1.38

1.24,1.53

1.6E−09

rs3081219

WDR72

15:53876165

C/CAG

0.13/291

1.31

1.19,1.44

Ca: 30/31/3

Co: 193/32/2

1.1E−08

0.98

0.18/79

1.22

0.87,1.40

0.08

0.99

1.29

1.19,1.41

1.0E−09

rs11070992

WDR72

15:53880517

G/A

0.14/291

1.28

1.19,1.39

Ca: 30/30/4

Co: 188/37/2

4.2E−08

0.96

0.19/79

1.25

0.98,1.53

0.04

0.99

1.28

1.18,1.38

2.0E−09

rs67619978

WDR72

15:53881471

A/ACACGAATT TCAGTTTGTA

0.14/291

1.28

1.19,1.39

Ca: 30/30/4

Co: 188/37/2

4.2E−08

0.95

0.18/79

1.24

1.02,1.55

0.04

0.98

1.27

1.18,1.38

2.1E−09

rs1065386

HLA-B

6:31324547

C/G

0.43/291

1.21

1.14,1.28

Ca: 3/36/25

Co: 89/111/27

3.0E−09

0.86

0.37/79

0.91

0.77,1.08

0.30

0.79

1.17

1.11,1.24

5.2E−08

rs10560003

GAP43/RP11-326J18.1

3:115378465

T/TAGAG

0.02/291

1.86

1.50,2.31

Ca: 55/8/1

Co: 227/0/0

2.1E−08

0.85

0.04/79

0.98

0.71,1.33

0.88

0.90

1.52

1.28,1.81

2.5E−06

rs72740408

AL713866.1

1:191105831

A/G

0.03/291

1.65

1.41,1.93

Ca: 47/16/1

Co: 225/2/0

1.1E−08

0.74

0.06/79

1.13

0.82,1.56

0.45

0.94

1.52

1.31,1.76

2.3E−08

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