Fig. 1: Molecular landscape of 22 tumors collected after rapid autopsy of two patients with metastatic uveal melanoma.

a Schematic of multiple metastasis and molecular studies. b, c Co-variant plot of deleterious variants found in Patients 1 and 2, respectively. The height of each colored bar represents the cancer cell fraction of that variant in the indicated sample. For Patient 1, letters correspond to tumors harvested from anatomic sites including: periocular tumor (A), liver segment 4/5 (B), liver segment 4B (C), periportal lymph node (D), 12th rib (E), perisplenic nodule (F), liver segment 2 (G), lung (H), supraclavicular lymph node (I), subcutaneous left abdomen (J), and subcutaneous right cheek (K). For Patient 2, letters correspond to tumor harvested from the indicated anatomic sites including: primary tumor (A), left upper lung (B), right upper lung (C), subcutaneous right chest (D), liver lesion 1 (E), liver lesion 2 (F), right caval lymph node (G), subcutaneous left chest (H), adrenal (I), omentum (J), and retroperitoneum (K). d, e Copy number variation (CNV) plot of all chromosomes for Patients 1 and 2, respectively. Blue indicates a loss and red indicated a gain. Chromosome numbers are labeled on the horizontal axis. Letters represent the same sample names in panels (b) and (c) for each respective patient.