Fig. 2: Multiregional tumor seeding analysis.
From: Multiregional genetic evolution of metastatic uveal melanoma
a Treeomic heatmap of Patient 1, showing the posterior probability of the presence of variants, with a color legend indicating probability of variant in each tumor sample. b Clonality tree and body map in Patient 1, indicating the inferred pattern of metastatic spread. Letters correspond to tumors harvested from indicated anatomic sites including: periocular tumor (A), liver segment 4/5 (B), liver segment 4B (C), periportal lymph node (D), rib (E), spleen (F), liver segment 2 (G), lung (H), supraclavicular lymph node (I), subcutaneous left abdomen (J), and subcutaneous right cheek (K). The dotted line represents a possible polyclonal seeding event. c Treeomic heatmap snapshots of Patient 2, showing the posterior probability of the presence of variants, with a color legend indicating probability of variant in each tumor sample. d Clonality tree and body map in Patient 2, indicating the inferred pattern of metastatic spread. Letters correspond to tumors harvested from indicated anatomic sites including: primary tumor (A), left lung (B), right lung (C), subcutaneous right chest (D), liver lesion 1 (E), liver lesion 2 (F), right caval lymph node (G), subcutaneous left chest (H), adrenal (I), omentum (J), and retroperitoneum (K).
