Fig. 3: Expression profile of T-cell priming markers in various types of cancer (N = 514).

Transcript abundance was normalized to internal housekeeping gene profiles and ranked (0–100) to standardized values by comparing to a reference population of 735 tumors spanning 35 histologies. This figure shows no pattern of expression that can be differentiated by tumor type. The expression profiles were stratified by rank values into “Low” (0–24), “Intermediate” (25–74), and “High” (75–100). See Methods as well. Colorectal (N = 140), pancreatic (N = 55), breast (N = 49), ovarian (N = 43), stomach (N = 25), sarcoma (N = 24), uterine (N = 24), lung (N = 20), liver and bile Duct (N = 19), esophageal (N = 17), neuroendocrine (N = 15), cancer of unknown primary (N = 13), head and neck (N = 12), small intentine cancer (N = 12), Melanoma (N = 6). Others include: cervical cancer (N = 5), bladder cancer (N = 4), gallbladder and extrahepatic bile duct cancers (N = 4), prostate cancer (N = 4), brain and nervous system cancers (N = 3), kidney and renal pelvis cancers (N = 3), squamous cell carcinoma of the skin (N = 3), thyroid cancer (N = 3), adrenal gland cancer (N = 3), lipomatous neoplasm (N = 2), mesothelioma (N = 2), basal cell carcinoma of the skin (N = 1), ocular melanoma (N = 1), primary peritoneal carcinoma (N = 1), and thymic cancer (N = 1). Each column represents a patient. red, green, and blue means high, intermediate and low expression respectively. BC breast cancer, CRC colorectal cancer, CUP cancer of unknown primary, H&NC head and neck cancer, LBC liver and bile duct cancer, LC lung cancer, NEC neuroendocrine cancer, OC ovarian cancer, PC pancreatic cancer, SC stomach cancer, SIC small intestine cancer, UC uterine cancer.