Fig. 4: Progression-free survival analysis stratified by debulking status. | npj Genomic Medicine

Fig. 4: Progression-free survival analysis stratified by debulking status.

From: Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease

Fig. 4

a Kaplan-Meier plots for patients in AGO-OVAR 11 with optimal (RD = 0, top) or suboptimal (RD > 0, bottom) debulking stratified by rs72845444 genotype. b Kaplan-Meier plots for high-grade serous patients with optimal (top) or suboptimal (bottom) debulking stratified by PPP2R5C mRNA levels in the AGO-OVAR 11 (top panel, RD = 0 vs RD > 0) and the TCGA cohort (bottom panel, RD < = 1 cm vs RD > 1 cm). PPP2R5C mRNA levels were measured by four different probes per study as indicated within the figures (Illumina IDs from the AGO-OVAR 11 dataset or specific probe set from the TCGA data accessed via KM-Plotter). For the TCGA dataset, patients were split by auto-selected best cutoff, and high-grade serous patients were chosen, followed by further selection of debulking status. Probe ID ILMN_1780913 captured PPP2R5C isoform 1, ILMN_1789283 mapped onto isoforms 1, 2, and 3, ILMN_2364971 matched isoforms 1, 2, and 3, and ILMN_1795846 matched isoform 3. Transcript isoforms indicated represent NM_002719 (1), NM_178586 (2) and NM_178587 (3) in the NCBI Genbank, respectively.

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