Table 1 Outcomes from GWAS and MAGMA analyses with and without adjustment for stage

From: Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease

Study Characteristics

Study Name

GIF (lambda)

SNPs above GWS

Genes from MAGMA at p < 10−5 (25Kb window)

Age-adjusted (invasive and non-invasive)

All OC - FIGO

0.995

  

Age-adjusted (invasive)

Invasive EOC - FIGO

1.001

  

Age-adjusted (high-grade serous)

HGSOC - FIGO

1.011

rs72845444 (10:131224242:A:G, p = 3.89x10−8) near MGMT

CABLES1 (p = 2.63 × 10−6)

Age and stage adjusted (invasive and non-invasive)

All OC + FIGO

0.981

 

FAM35A (p = 6.36 × 10−6)

Age and stage-adjusted (invasive)

Invasive EOC + FIGO

0.986

  

Age and stage adjusted (high-grade serous)

HGSOC + FIGO

1.004

 

PPP2R5C (p = 4.78 × 10−6)

  1. Most significant variants and genes for the GWAS and MAGMA analyses in all OC (invasive and non-invasive), invasive OC and high-grade serous-only ovarian cancer (HGSOC) patient groups are noted. The analyses were run just age-adjusted or age and stage adjusted, respectively. Associations at p < 5 × 10−8 were considered significant, and MAGMA p < 10−5 was considered noteworthy for follow-up.
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