Fig. 4: ERG measurements before and after CLE-induced retinal damage. | npj Genomic Medicine

Fig. 4: ERG measurements before and after CLE-induced retinal damage.

From: SLC16A8 is a causal contributor to age-related macular degeneration risk

Fig. 4

A-, b-, and c-wave (A–C; left panels) ERG amplitudes (µV) were measured at baseline and Day 7 for Slc16a8-WT, Het, and KO mice. Data is plotted as peak amplitudes (Mean ± SD), all n ≥ 12 eyes. A–C; right panels: Percent change following CLE are shown for A-, b- and c-waves (Mean ± SD). A For a-wave amplitudes (µV) at baseline: Slc16a8 WT (213.87 ± 15.5), Het (177.63 ± 32.8), and KO (125.15 ± 26.14). A-wave baseline all P < 0.0001. A-wave amplitudes (µV) day 7: WT (90.30 ± 20.6), Het (38.39 ± 15.1), and KO (67.56 ± 23.96). At day 7 for WT vs. Het (P < 0.0001), WT vs. KO (P = 0.0474), and Het vs. KO (P = 0.0018). A-wave % change WT (-57.84 ± 9.8), Het (-77.70 ± 9.5), and KO (-43.68 ± 23.0). A-wave % change WT vs. Het (P < 0.005), WT vs. KO (P < 0.05), and Het vs. KO (P < 0.0001). B B-wave baseline amplitudes (µV): WT (468.66 ± 77.3), Het (419.65 ± 79.1), and KO (202.97 ± 57.5). B-waves baseline: WT vs. Het (P = 0.0443), WT vs. KO (P < 0.0001), and Het vs. KO (P < 0.0001). Day 7 B-wave amplitudes (µV): WT (239.78 ± 50.67), Het (100.15 ± 51.53), and KO (68.60 ± 23.33). Day 7 b-waves: WT vs. Het and WT vs. KO (both P < 0.0001). B-wave % change WT (-46.3 ± 16.2), Het (-75.60 ± 13.0), and KO (-62.67 ± 18.7). B-wave % change WT vs Het (P < 0.0001) and WT vs. KO (P < 0.05). C C-wave amplitudes (µV) at baseline: WT (478.57 ± 101.43), Het (396.01 ± 72.0), and KO (247.3 ± 86.10). C-wave baseline: WT vs. Het (P < 0.01), WT vs. KO (P < 0.0001), and Het vs. KO (P < 0.0001). Day 7 C-wave amplitudes (µV): WT (286.79 ± 65.24), Het (114.41 ± 46.0), and KO (247.24 ± 61.2). Day 7 WT vs. Het (P < 0.0001), WT vs. KO (P < 0.0001). C-wave % change WT (-37.80 ± 22.8), Het (-70.0 ± 12.64), and KO (12.26 ± 45.87). C-wave % change WT vs. Het (P < 0.01), WT vs. KO (P < 0.0001), and Het vs. KO (P < 0.0001). For a, b, and c-wave analysis: (A–C; left panels) Mixed-effects analysis: a-wave: F(2, 49) = 25.61, P < 0.0001, b-wave: F(2, 49) = 19.02, P < 0.0001, c-wave: F(2, 99) = 31.41, P < 0.0001); multiple comparisons are between groups within timepoints, Sidak post-hoc., (A-C; right. panels) One-way ANOVA (a-wave: F(2, 49) = 27.13, P < 0.0001, b-wave: F(2, 49) = 16.82, P < 0.0001, c-wave: F(2, 48) = 39.14, P < 0.0001), Sidak post-hoc, % Change computed as (Day 7–Baseline)/Baseline *100.

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