Fig. 6 | npj Parkinson's Disease

Fig. 6

From: Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

Fig. 6

PD susceptibility genes do not enrich in brain-related cell types. a PD susceptibility genes were derived from MAGMA analyses and a study attempting to prioritise genes in PD using TWAS and colocalisation analyses.26 Genes overlapping between the two sets were removed, resulting in a list of 89 genes. Bootstrapping tests performed using the EWCE method revealed no enrichment of PD susceptibility genes in the major cell-type classes (b) or their cell subtypes (c) from the Linnarsson single-cell RNA-sequencing dataset. Gene lists and numerical results are available in Supplementary Table 5

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