Fig. 6: Effect of MPTP treatment on the number of HuC/D-, nNOS- and VIP-ir, in the proximal and distal colon of naïve control and MPTP-treated common marmosets. | npj Parkinson's Disease

Fig. 6: Effect of MPTP treatment on the number of HuC/D-, nNOS- and VIP-ir, in the proximal and distal colon of naïve control and MPTP-treated common marmosets.

From: Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate

Fig. 6

Inset panels (a, e) show HuC/D-ir; (b, f) show nNOS-ir and (c, g) show VIP-ir in the proximal (a) and distal (c) colon of naïve control and MPTP-treated common marmosets. Panels (d, h) show triple immunofluorescence for HuC/HuD (blue), nNOS (red) and VIP (green) in the myenteric plexus from proximal (main panel a) and distal (main panel c) colon of naϊve and MPTP-treated animals. Quantitative analysis of nNOS- and VIP-ir neurons in MPTP-treated marmosets compared to naϊve controls in the proximal and distal colon is shown in the main panels (b) and (d), respectively. The number of immunoreactive neurons are expressed as mean ± SEM. *P < 0.05 compared to naïve control (Students t-test). White arrows indicate co-localisation of nNOS and VIP. The scale bar in panel (aa) indicates 100 µm.

Back to article page