Table 1 Demographic, clinical, and biomarker characteristics of the DLB clusters.
From: MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
|  | C1 (N = 49) Cortical predominant | C2 (N = 76) Fronto-occipital predominant | C3 (N = 40) Subcortical predominant | statistic (p-value) | post-hoc | Number of subjects with available data |
|---|---|---|---|---|---|---|
Age, mean (SD) | 73.43 (8.02) | 69.05(7.52) | 63.68(8.23) | 17.048 (<0.001) | C1 > C2 C1 > C3 C2 > C3 | C1:49 C2:76 C3:40 |
Years of education, mean (SD) | 15.02(3.61) | 13.24(3.90) | 12.60 (3.80) | 5.117 (0.007) | C1 > C2 C1 > C3 | C1:49 C2:76 C3:40 |
MMSE, mean (SD) | 21.57(5.49) | 22.93(5.27) | 24.50(4.38) | 3.579 (0.030) | C3 > C1 | C1:49 C2:75 C3:40 |
Sex, male/female (male %) | 35/14 (71%) | 60/16 (79%) | 24/16 (60%) | 4.696 (0.096) | Â | C1:49 C2:76 C3:40 |
Disease duration (years), mean (SD) | 5.11 (3.63) | 5.09 (3.46) | 7.25 (6.00) | 2.961 (0.056) | Â | C1:32 C2:59 C3:32 |
Visual hallucinations (presence/absence) | 31/16 (66%) | 39/36 (52%) | 19/21 (48%) | 3.461 (0.177) | Â | C1:47 C2:75 C3:40 |
Cognitive fluctuations (presence/absence) | 32/13 (71%) | 63/11 (85%) | 36/2 (95%) | 8.614(0.013) | C3 > C1 | C1:45 C2:74 C3:38 |
Probable RBD (presence/absence) | 35/10 (78%) | 57/13 (81%) | 25/10 (71%) | 1.362 (0.506) | Â | C1:45 C2:70 C3:35 |
Parkinsonism (presence/absence) | 43/4 (94%) | 68/8 (90%) | 31/9 (78%) | 4.473(0.107) | Â | C1:47 C2:76 C3:40 |
APOE genotype, ε4 carriers (presence/absence) | 18/31 (37%) | 38/34 (53%) | 13/25 (34%) | 4.770(0.092) |  | C1:49 C2:72 C3:38 |
AD co-pathology (presence) | 7% | 15% | 6% | 2.352 (0.309) | Â | C1:29 C2:60 C3:33 |
White matter hyperintensities, mean (SD) | 21.37 (15.41) | 14.55 (13.13) | 12.43(7.96) | 6.230 (0.002) | C1 > C2 C1 > C3 | C1:49 C2:76 C3:40 |
Center of origin (Mayo Clinic/ Prague/ Strasbourg/ Amsterdam) | 28/14/4/3 | 26/12/15/23 | 14/3/15/8 | 27.800 (p < 0.001) | C1 vs C3 C1 vs C2 | C1:49 C2:76 C3:40 |
