Fig. 3: The DNB gene MAPKAPK2 regulates neighbouring gene SERPINE1 expression in the cellular senescence pathway. | npj Parkinson's Disease

Fig. 3: The DNB gene MAPKAPK2 regulates neighbouring gene SERPINE1 expression in the cellular senescence pathway.

From: MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patients

Fig. 3

a Multiple DNB genes and neighbouring genes were enriched in the cellular senescence pathway. Blue borders indicate DNB genes, and red borders indicate differentially expressed neighbouring genes. The light blue dashed box represents a portion of the pathway studied in detail. b MAPKAPK2 regulated SERPINE1 expression and activated the cellular senescence pathway. Diamonds represent DNB genes, rectangles represent differentially expressed neighbouring genes, and ovals represent other genes that are neither DNB genes nor neighbouring genes. The colour indicates the expression level of a gene, and the green background indicates that the expression levels of genes that are not shown.

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