Fig. 2: Metabolic modeling of GBA-PD. | npj Parkinson's Disease

Fig. 2: Metabolic modeling of GBA-PD.

From: Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids

Fig. 2

a Venn diagram representation of the structural model analysis. b Comparison of model composition by reactions. Reactions found exclusively in control models (green) or in GBA-PD (purple) were mapped to the Recon 3 subsystems, and the top five most different subsystems based on the reaction number are listed for each condition. EDR = exchange/demand reaction, GP = glycerophospholipid. c The top 10 most different subsystems between control (CTRL1 and CTRL2) and GBA-PD (PD1 and PD2) models after pooling the exclusive reactions of the two conditions. The size and color of the dot represent the number of reactions per subsystem. The ___location in relation to the x-axis represents the size of the subsystem in the generic Recon3. Subsystems are positioned on the y-axis in alphabetical order. GP = glycerophospholipid, ER = endoplasmic reticulum. d Similarity index of flux variability analysis optimizing for ATP demand for subsystems of interest. SI between CTRL1 vs CTRL2 and SI between PD1 and PD2 models were compared, as well as the SI between the CTRL (CTRL1 and CTRL2) and GBA-PD (PD1 and PD2). SI of 0 represents a complete mismatch in flux variability between the models, whereas a SI of 1 represents the highest similarity in flux variability. PI = Phosphatidylinositol, ER = endoplasmic reticulum, GP = glycerophospholipid.

Back to article page