Fig. 3: EV-associated miRNAs for distinguishing iRBD and PD. | npj Parkinson's Disease

Fig. 3: EV-associated miRNAs for distinguishing iRBD and PD.

From: Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease

Fig. 3

a Unsupervised clustering heatmap of differentially expressed miRNAs in PD patients (blue) and iRBD patients (red). Each row represents a differentially expressed miRNA. b MA-plot of the differentially expressed miRNAs between PD patients and iRBD patients. The up- or down-regulated miRNAs are shown in red or blue, respectively. c Three-dimensional scatter plot of PCA for the differentially expressed miRNAs between PD patients and iRBD patients. d Confusion matrix of the SVM classifier for PD patients and iRBD patients in the training (left) and validation (right) sets. Sensitivity, specificity, and accuracy are shown at the bottom. e ROC curve of the SVM classifier in the training (red, n = 65) and validation (blue, n = 44) sets. AUC values and 95% confidence intervals are shown in the plot.

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