Fig. 4: Genetic correlations between PD and brain IDPs.
A Manhattan plot illustrates the genetic correlations between PD and 3935 IDPs. The x-axis represents the categories of IDPs, while the y-axis represents the significance of the correlation. Each point represents the correlation result between PD and a brain IDP, with red indicating a positive correlation, blue indicating a negative correlation, and gray indicating no significant correlation between them. B The proportion of different categories of IDPs genetically correlated with PD. The size of the circles represents the proportion. C The bar chart shows the enrichment significance of different categories of IDPs. The numbers within the squares indicate the respective counts of different IDPs that are significantly genetically correlated with PD, and the y-axis represents the -log10(p) values from the hypergeometric distribution test.
