Fig. 3
From: Humanizing the mdx mouse model of DMD: the long and the short of it
mdx4cv/mTRG2 animal model faithfully recapitulates the skeletal and the cardiac phenotype of DMD. Molecular and functional characterization of skeletal muscle and cardiac phenotypes in the mdx4cv/mTRG2 double knockout mouse. Overall, mdx4cv/mTRG2 exhibited decreased life span. In the skeletal muscle, mdx4cv/mTRG2 exhibited decreased exercise capacity, decreased muscle strength, histological evidence of muscular dystrophy, and kyphosis. In the heart, mdx4cv/mTRG2 displayed cardiac dysfunction as measured by MRI, histology, ECHO, ECG, and electron microscopy. Figure adapted from prior mdx4cv/mTRG2 studies108,109
