Fig. 1: Lengthscale variations between mouse and human liver architecture.
From: Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside
a Schematic showing elements of liver architecture and regions which can vary between mice and humans. Top panel: Mouse and human livers which have a repeating lobular structure. Middle panel: Cross sectional representation of a liver lobule, highlighting the portocentral axis and portal vein diameter, which are statistically different in size between mouse and humans. Lower panel: Close up of a sinusoid, highlighting the sinusoidal endothelium and associated fenestrae. b, c Schematics demonstrating differences between sites of hepatic cell therapy administration in mouse and humans. Sp spleen, Pv portal vein, Spv splenic vein, i/v intravenous, lv lateral vein. Brown polyhedral cells represent hepatocytes, purple cells represent macrophages.
