Fig. 4: Heterogeneity of the resting MSC secretome between MSC sources.

a Venn diagrams represent the total amount of identified proteins in CM from different sources (n = 4 iMSC, n = 3 BM.MSC, n = 3 UC.MSC, n = 3 UC.MSC), where more exclusive proteins were found in iMSC secretomes. b PCA loadings were plotted identifying specific proteins driving the separation of resting MSC secretomes by sources (iMSC = yellow, BM.MSC = blue, AT.MSC = purple, UC.MSC = green). c Heat map showing hierarchical Euclidean (average) clustering of resting MSC secretomes (x) and K-means clustering (n = 6) of secreted proteins (y) based on intensity (red = more intense, blue = less intense). d Top 10 overrepresented GO BP terms for each K-means cluster of resting MSC secretomes were plotted as horizontal bar graphs. Bar length indicates fold enrichment, colour indicates significance (−log10 FDR) as per the legend. Figures were generated using iDEP1.1⁹⁶.