Table 1 Top biological process terms overrepresented amongst DE proteins upregulated in either resting or licensed MSC secretomes
Group | Biological process | Fold enrichment | FDR |
|---|---|---|---|
Overrepresented in licensed | Immune system process | 4.55 | 3.69E-10 |
Immune response | 5.78 | 3.69E-10 | |
Positive regulation of immune system process | 8.08 | 2.90E-08 | |
Regulation of immune system process | 5.91 | 8.81E-08 | |
Humoral immune response | 17.97 | 2.79E-07 | |
Biological process involved in interspecies interaction between organisms | 5.35 | 2.79E-07 | |
Response to biotic stimulus | 5.45 | 7.45E-07 | |
Regulation of immune response | 7.44 | 8.95E-07 | |
Response to external biotic stimulus | 5.23 | 3.64E-06 | |
Response to other organism | 5.23 | 3.64E-06 | |
Positive regulation of apoptotic cell clearance | 120.61 | 4.10E-06 | |
Regulation of apoptotic cell clearance | 109.65 | 5.66E-06 | |
Adaptive immune response | 9.35 | 6.31E-06 | |
Positive regulation of immune response | 9.00 | 8.36E-06 | |
Defence response | 4.45 | 1.93E-05 | |
Response to molecule of bacterial origin | 12.06 | 1.94E-05 | |
Complement activation | 35.90 | 2.04E-05 | |
Response to bacterium | 7.81 | 2.08E-05 | |
T cell migration | 35.06 | 2.08E-05 | |
Innate immune response | 6.02 | 5.40E-05 | |
Chemokine-mediated signalling pathway | 28.45 | 5.40E-05 | |
Response to chemokine | 26.22 | 7.14E-05 | |
Cellular response to chemokine | 26.22 | 7.14E-05 | |
Neutrophil chemotaxis | 24.51 | 9.25E-05 | |
Response to lipopolysaccharide | 11.23 | 1.13E-04 | |
Overrepresented in resting | Collagen fibril organisation | 89.97 | 4.84E-05 |
Extracellular matrix organisation | 24.71 | 9.24E-05 | |
Collagen metabolic process | 64.38 | 9.24E-05 | |
Extracellular structure organisation | 24.64 | 9.24E-05 | |
External encapsulating structure organisation | 24.43 | 9.24E-05 | |
Cartilage development involved in endochondral bone morphogenesis | 159.49 | 9.24E-05 | |
Endochondral bone morphogenesis | 89.20 | 3.82E-04 | |
Bone morphogenesis | 52.11 | 1.69E-03 | |
Skin morphogenesis | 219.30 | 2.38E-03 | |
Supramolecular fibre organisation | 9.93 | 4.41E-03 | |
Endochondral ossification | 120.99 | 6.02E-03 | |
Replacement ossification | 120.99 | 6.02E-03 | |
Skeletal system development | 12.49 | 8.76E-03 | |
Cartilage development | 24.83 | 8.76E-03 | |
Anatomical structure morphogenesis | 4.28 | 1.00E-02 | |
Collagen biosynthetic process | 76.28 | 1.00E-02 | |
Skeletal system morphogenesis | 22.49 | 1.00E-02 | |
Bone development | 21.39 | 1.00E-02 | |
Circulatory system development | 7.63 | 1.00E-02 | |
Positive regulation of epithelial to mesenchymal transition | 67.48 | 1.03E-02 | |
Cellular response to transforming growth factor beta stimulus | 19.86 | 1.03E-02 | |
Response to transforming growth factor beta | 19.42 | 1.05E-02 | |
Connective tissue development | 18.60 | 1.10E-02 | |
Blood vessel development | 9.56 | 1.20E-02 | |
Vasculature development | 9.17 | 1.35E-02 | |
Cellular response to amino acid stimulus | 46.17 | 1.66E-02 |
