Fig. 3: Main effects of N-Back task and treatment on BOLD response. | Schizophrenia

Fig. 3: Main effects of N-Back task and treatment on BOLD response.

From: Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy

Fig. 3

A Performance at different levels of N-Back difficulty. B Whole-brain analysis cluster corrected p < 0.05 showing the main effect of task for all participants. Task-positive clusters are shown in red and task-negative clusters are in blue. B Main effect of treatment in hippocampus and schizotypy in DLPFC, comparing all 3 levels of N-Back with 0-Back. C ROI analysis showing effect of schizotypy in left DLPFC and loss of hippocampal deactivation after ulotaront treatment. D Whole-brain analysis showing effect of ulotaront versus placebo (–12 42 26, voxels 419) and amisulpride versus placebo (–26 38 36, voxels 729) in left frontal pole. E ETB analysis of emotional processing in LS and HS subjects outside the scanner and effects after treatment with placebo, ulotaront or amisulpride. The analysis assessed reaction time in the emotional categorization task and the number of both positive and negative emotional words recalled. BOLD blood oxygen level-dependent, DLPFC dorsolateral prefrontal cortex, ETB emotional test battery, HS high schizotypy, LS low schizotypy, ROI region of interest. Error bars are standard errors of the mean.

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