Table 3 Comparison of Beta-values of DMPs in baseline in Study Period II.

Beta value	SCZ (n = 109)	MUD with MIP (n = 99)	MUD-only (n = 150)	NC (n = 282)	Pairwise comparisons
Beta value	Mean ± SD1	Mean ± SD2	Mean ± SD3	Mean ± SD4	Pairwise comparisons
CSNK1E	0.003 ± 0.001	0.005 ± 0.006	0.005 ± 0.003	0.005 ± 0.004	2 > 3^*, 2 > 4^*
APOL3	0.159 ± 0.020	0.316 ± 0.037	0.156 ± 0.027	0.200 ± 0.031	2 > 3^*, 2 > 4^*
UBA6	0.273 ± 0.039	0.332 ± 0.052	0.292 ± 0.048	0.229 ± 0.050	1 > 4^,, 2 > 3^, 2 > 4^**
KIF17	0.117 ± 0.024	0.143 ± 0.040	0.109 ± 0.030	0.108 ± 0.034	1 > 4^,, 2 > 3^, 2 > 4^**
SETDB1	0.081 ± 0.022	0.025 ± 0.007	0.089 ± 0.027	0.094 ± 0.030	–
MLLT3	0.380 ± 0.034	0.452 ± 0.048	0.381 ± 0.039	0.383 ± 0.042	2 > 3^*, 2 > 4^*
GRM8	0.205 ± 0.040	0.261 ± 0.074	0.161 ± 0.053	0.161 ± 0.050	1 > 4^*, 1 > 3^, 2 > 3^, 2 > 4^*

DMPs differentially methylated positions, SCZ schizophrenia, MUD methamphetamine use disorder, MIP methamphetamine-induced psychotic disorder, MUD-only methamphetamine use disorder without methamphetamine-induced psychotic disorder, NC normal controls.
^***p < 0.001, ^**p < 0.01 in Mann–Whitney U test.

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