Fig. 1: Effect of dexamethasone administration on muscle weight and function.

a Schematic diagram illustrating the study design. Comparison of body weight b and food intake c of mice in the DEX- (10 mice) and DEX+ (10 mice) groups from week 1 to week 8. Grip strength dynamics d in the DEX- and DEX+ groups from week 1 to week 8. Comparison of gastrocnemius muscle weight e and soleus muscle weight f between DEX- and DEX+ groups after dexamethasone treatment for 7 weeks. Values are means ± sem. Differences were assessed by independent samples t-test and denoted as follows: ns, no significance; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. (DEX-: without dexamethasone injection; DEX + : dexamethasone injection).