Fig. 2: Overview of other visible neural network architectures used in the additional analyses. | npj Systems Biology and Applications

Fig. 2: Overview of other visible neural network architectures used in the additional analyses.

From: Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data

Fig. 2

The ME + GE network base (a) serves as a basis for all networks displayed. b Pathway layers are added to this base by grouping genes and connecting them to their corresponding KEGG pathway. The KEGG functional pathways consist of a three-layer hierarchical structure with 321, 44 and 6 nodes each. To compare this network to an equivalent regular dense network (d) fully connected layers with the same dimensions were attached to the ME + GE base. Covariates were integrated in the network by adding a single layer with the covariates (c) to the base, or by adding the covariates to each combined gene representation in the ME + GE network (e).

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