Fig. 5: Neutralization potency elicited by SARS-CoV-2 S6P-HBsAgs in mice preimmunized with Recombivax HB. | npj Vaccines

Fig. 5: Neutralization potency elicited by SARS-CoV-2 S6P-HBsAgs in mice preimmunized with Recombivax HB.

From: Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

Fig. 5

A Immunization schema of SARS-CoV-2 constructs. SARS-CoV-2 S2P(1-1273) DNA matching the sequence of mRNA-1273, S6P(1-1206), S6P-12-HBsAg and S6P-16-HBsAg were administered to mice preimmunized with Recombivax HB. B Neutralization ID50s against WA1 (left) and B.1.1.529 (BA.1, right) pseudoviruses at week 10. The ID50s were shown in a logarithmic scale in the box and whiskers format. The data points in the median quartile of each group were boxed. The error bars represent 95% confidence interval for the ID50s. The doses and immunogens were indicated. The data from each animal were shown as dots, diamonds and triangles for 10, 2, and 0.4 µg, respectively. The data points were shown in black, yellow green, red and blue for S2P(1-1273), S6P(1-1206), S6P-12-HBsAg and S6P-12-HBsAg, respectively. The geometric mean ID50 values were indicated. The statistical analyses were performed using the two-way ANOVA test following log transformation of the data. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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