Fig. 6: Mosaic VLPs immunization elicits cross-reactive neutralizing antibody responses in mice against H1N1- and H3N2-representative viruses. | npj Vaccines

Fig. 6: Mosaic VLPs immunization elicits cross-reactive neutralizing antibody responses in mice against H1N1- and H3N2-representative viruses.

From: A mosaic influenza virus-like particles vaccine provides broad humoral and cellular immune responses against influenza A viruses

Fig. 6

BALB/c mice were vaccinated with VLPs and compared to QIV-vaccinated mice. The neutralizing antibody response to H1N1 (A) or H3N2 (B) representative strains was determined by Microneutralization assay in mice immunized with boost immunization. A heatmap of Microneutralization titers was further constructed to better visualize cross-reactive antibody response for each vaccine. Data are presented as the mean with standard error (SEM) (n = 5; two-way ANOVA with Tukey multiple comparison), *P < 0.05, **P < 0.01.

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