Fig. 4: Evaluation of tolerability of SARS-CoV-2 mRNA-LNP vaccines in BALB/c mice. | npj Vaccines

Fig. 4: Evaluation of tolerability of SARS-CoV-2 mRNA-LNP vaccines in BALB/c mice.

From: Durable cross-protective neutralizing antibody responses elicited by lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccines

Fig. 4

a Body weight changes of BALB/c mice in the course of vaccination study. The arrows depict the time points of immunization (week 0, 3, and 11). b Serum concentration of ALT, BUN, and LDH detected at the endpoint (week 28). Mean ± SD (n = 5); ns: nonsignificant (statistical analysis was performed using one-way ANOVA with Tukey’s post hoc test). c Representative H&E-stained sections of the liver, spleen, and heart were harvested at the endpoint. The scale bars represent 100 µm.

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