Fig. 1: EILV/CHIKV protects cynomolgus macaques from WT CHIKV infection 1 year after a single dose vaccination. | npj Vaccines

Fig. 1: EILV/CHIKV protects cynomolgus macaques from WT CHIKV infection 1 year after a single dose vaccination.

From: A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

Fig. 1

NHPs were vaccinated with a low (LD) or high doses (HD) of EILV/CHIKV, CHIKV 181/25 or PBS (mock). At day 350, all animals were implanted with electronic data loggers as temperature sensor and challenged subcutaneously with 1.0 × 105 PFU of WT La Reunion strain of CHIKV at day 370. A Study design and vaccination timeline [Created with BioRender.com Wang, T. (2023) BioRender.com/o29z240]. B Body temperature changes were recorded every 15 min and reported as mean ± standard error of the mean (SEM) starting 7 days before to 14 days after infection with WT CHIKV strain La Réunion. C Viremia were measured by plaque assays at indicated days post-challenge (PC). UD: Undetectable. Data are presented as means ± SEM.

Back to article page