Extended Data Fig. 2: Skin plaster assessment of dorsal skin after COL1A1-EV treatment. | Nature Biomedical Engineering

Extended Data Fig. 2: Skin plaster assessment of dorsal skin after COL1A1-EV treatment.

From: Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Extended Data Fig. 2

a, Microscopic observations of dorsal skin and skin replicas. Scale bar, 5 mm. b, Mean wrinkle depth in skin replicas (n = 4 for all groups, ※※※P < 0.001 COL1A1-EVs vs Saline; **P = 0.0025 COL1A1-LNPs vs Saline; +++P < 0.001 COL1A1-EVs vs COL1A1-LNPs). c, Mean wrinkle length analysed on skin replicas (n = 4 for all groups, #P = 0.0203 Unloaded EVs vs Saline; *P = 0.0405 COL1A1-LNPs vs Saline; ※※※P < 0.001 COL1A1-EVs vs Saline; ++P = 0.0015 COL1A1-EVs vs COL1A1-LNPs).All data are from three independent experiments and are presented as means ± SEM. One-way analysis of variance (ANOVA) was used for the comparisons in (b, c). NS, not significant.

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