Extended Data Fig. 9: Correlation between cochlear nerve action potentials (CNAP) signals and degrees of nerve damage.
a-f, Photos of the same rabbit sciatic nerve under various degrees of sharp damage using micro-scissors and corresponding evoked Electromyography (EMG) signals. g, Comparison of evoked EMG amplitudes with soft PEDOT electrodes under various degrees of sharp damage. P values for comparing the EMG amplitudes are as follows: G 0 (n = 4 nerves) versus G I (n = 4 nerves), P = 0.007; G I (n = 4 nerves) versus G II (n = 4 nerves), P = 0.005; G II (n = 4 nerves) versus G III (n = 4 nerves), P = 0.007; G III (n = 4 nerves) versus G IV (n = 4 nerves), P = 0.011; h, Amplitudes of Brainstem auditory evoked potentials (BAEP) and CNAP under various degrees of cochlear nerve damage. CNAP was recorded from soft PEDOT electrodes wrapping around the nerve. P values for comparing the amplitudes are as follows: CNAP: No damage (n = 4 nerves) versus Severe damage (n = 4 nerves), P < 0.001; BAEP (V I): No damage (n = 4 nerves) versus Severe damage (n = 4 nerves), P < 0.001; BAEP (V I): No damage (n = 4 nerves) versus Severe damage (n = 4 nerves), P < 0.001. All error bars denote s.d. *P < 0.05; **P < 0.01; ***P < 0.001; paired, two-tailed student’s t-test was used for g; unpaired, two-tailed student’s t-test was used for h.
