Extended Data Fig. 1: The cGAS-STING pathway is crucial for DNA-induced cell death in mouse T cells. | Nature Biomedical Engineering

Extended Data Fig. 1: The cGAS-STING pathway is crucial for DNA-induced cell death in mouse T cells.

From: Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway

Extended Data Fig. 1

a, Fold change of cell number and cell viability at 24 h and 120 h post-EP. Wildtype, Sting–/– or Cgas–/– mouse T cells were electroporated with 1 μg plasmid (3.5 kb). b, Fold change of cell number and cell viability at 24 h and 120 h post-EP. WT or Sting−/− mouse T cells infected with empty vector or indicated STING protein upon DNA electroporation or MOCK electroporation. EP condition for this figure: P3-DN100. Data represent mean ± SD, each dot represents biological replicate, n = 3. Statistical significance was determined by two-way ANOVA with Tukey’s multiple comparisons test in a and one-way ANOVA with Dunnett’s multiple comparisons test in b.

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