Extended Data Fig. 2: All human implants experience about 100-fold increased mechanical stress compared to standard murine implants. | Nature Biomedical Engineering

Extended Data Fig. 2: All human implants experience about 100-fold increased mechanical stress compared to standard murine implants.

From: Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells

Extended Data Fig. 2

(a) Schematic of standard murine implants and and three commonly used human implants: breast implants, pacemakers, and neurostimulator batteries. (b) FE modeling of standard murine models of FBR reveals minimal mechanical stress at the implant-tissue interface. FE modeling reveals high mechanical stress ( ~ 100-fold higher) around human implants including breast implants, pacemakers and neurostimulator batteries.

Back to article page